Systematic review protocol on Bacillus Calmette-Guerin (BCG) revaccination and protection against tuberculosis

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Protocol for a Systematic Review: Bacillus Calmette- Guerin (BCG) Revaccination and Protection Against Tuberculosis

Background: The length of the protective efficacy of BCG vaccine plays an important role in the establishment of vaccination policies. Revaccination with two or more doses is supposed to boost up the immunity. However, the effectiveness of BCG revaccination has been questioned. It was argued that revaccination may increase the rate of tuberculin conversion but does it result in more sustained r...

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Bacillus Calmette-Guerin (BCG) lymphadenitis-changing trends and management.

BACKGROUND Bacillus Calmette-Guérin (BCG) vaccination is performed as a part of expanded Programme of Immunization (EPI). Suppurative lymphadenitis is the common complication of BCG vaccination. The optimum treatment for this complication is debated. METHODS All cases of BCG lymphadenitis presenting to pediatric surgical service over a 17-year study period were reviewed to determine the optim...

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Effectiveness of Bacillus Calmette-Guerin for Tuberculosis Prevention Among Chinese People: Systematic Review and Meta-analysis

Background: Our previous study showed that the protective effect of Bacillus Calmette-Guerin (BCG) declined with time, which is supported by a following study saying "BCG vaccination protection against tuberculosis varies between populations, to an extent that cannot be attributed to chance alone". Objective: To investigate BCG protective effect among Chinese people, so as to update the develop...

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Infantile osteoarticular tuberculosis misdiagnosed as Bacillus Calmette-Guerin related osteomyelitis

Tuberculosis, a re-emerging public health problem, is uncommon in infancy. Two healthy completely immunized infants presenting with manifestations compatible with osteoarticular infection required surgical debridement. The cultures of the specimens were positive for M. tuberculosis (MTB) complex comprised multiple subspecies. One case was misdiagnosed as a Bacillus Calmette-Guerin (BCG) related...

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Miliary Tuberculosis that Developed after Intravesical Bacillus Calmette-Guerin Therapy

As a treatment for superficial transitional cell carcinoma, Bacillus Calmette-Guerin (BCG) intravesical instillation can rarely cause unpredictable systemic side effects. We describe a patient admitted due to continuous pyrexia and general fatigue. He was previously treated with intravesical BCG. Laboratory data indicated a hepatic disorder, and chest computed tomography revealed extensive bila...

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ژورنال

عنوان ژورنال: BMJ Open

سال: 2019

ISSN: 2044-6055,2044-6055

DOI: 10.1136/bmjopen-2018-027033